Description

2,3,4,6-Tetramethyl-1-Fluorobenzene is a highly substituted fluorinated aromatic compound that serves as a valuable and versatile building block in advanced organic synthesis. Its unique structure, featuring a fluorine atom on a heavily methylated benzene ring, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials industries who require precise fluorination and steric control in their synthetic pathways.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drugs where the fluorine atom can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the tetramethyl and fluorine groups contribute to specific biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Materials: Acts as a core or side-chain component in the synthesis of specialty organic electronic materials, influencing mesomorphic properties and charge transport characteristics.
• Ligand & Catalyst Development: Serves as a precursor for creating sterically demanding, electron-tuning ligands used in homogeneous catalysis for fine chemical production.
• Fluorinated Polymer Research: Employed as a monomer or modifier in the research and development of high-performance polymers with enhanced chemical resistance, thermal stability, or low surface energy.
• Chemical Reference Standard: Utilized as a high-purity analytical standard in chromatography (GC, HPLC) and spectroscopy for method development and quality control in related chemical processes.

Basic Information

Product Name	2,3,4,6-Tetramethyl-1-Fluorobenzene
CAS No.	319-91-5
Molecular Formula	C10H13F
Molecular Weight	152.21 g/mol
Synonyms	1-Fluoro-2,3,4,6-tetramethylbenzene; Fluoropentamethylbenzene (common name); 2,3,4,6-Tetramethylfluorobenzene; Pentamethylfluorobenzene; F-Pentamethylbenzene; 319-91-5; Fluoromesitylene derivative
EINECS	Contact for details

Quality Control

Our 2,3,4,6-Tetramethyl-1-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids and strong bases. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (20°C)	~0.95 g/mL
Refractive Index (n20D)	~1.48

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.