Description

1-Naphthalenesulfonyl Fluoride is a specialized organosulfur compound featuring a sulfonyl fluoride functional group. This reactive moiety makes it a valuable building block and reagent in advanced organic synthesis, particularly for creating sulfonamide linkages. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require high-purity intermediates for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Chemical Biology Probe: Used as a reactive handle in activity-based protein profiling (ABPP) and chemoproteomics to study enzyme function.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with sulfonamide backbones.
• Polymer Chemistry: Monomer or cross-linking agent for producing specialty polymers with specific thermal or chemical resistance properties.
• Material Science Research: Employed in surface modification and the development of advanced functional materials.
• Organic Synthesis Reagent: Acts as a sulfonylating agent in various nucleophilic substitution reactions to introduce the naphthalenesulfonyl group.

Basic Information

Product Name	1-Naphthalenesulfonyl Fluoride
CAS No.	317-55-5
Molecular Formula	C₁₀H₇FO₂S
Molecular Weight	210.22 g/mol
Synonyms	1-Naphthalenesulfonyl fluoride; α-Naphthalenesulfonyl fluoride; 1-Naphthylsulfonyl fluoride; NSC 404080; Naphthalene-1-sulfonyl fluoride; 1-Fluorosulfonylnaphthalene
EINECS	206-268-3

Quality Control

Our 1-Naphthalenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its reactivity as a strong acid/organic solvent, handle with appropriate personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.