Description

4-Fluoronaphthalene-1-Sulfonyl Chloride is a specialized aromatic sulfonyl chloride derivative, serving as a high-value synthetic intermediate in advanced organic synthesis. Its core value proposition lies in its dual reactive sites—the sulfonyl chloride group and the fluorine substituent—enabling precise molecular construction for complex chemical architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity building blocks for drug discovery and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers and advanced functional materials.
• Fluorescent Probe & Dye Chemistry: The naphthalene core makes it a suitable starting material for synthesizing fluorophores and chromophores for analytical and diagnostic applications.
• Chemical Biology Research: Employed in activity-based protein profiling (ABPP) and the development of covalent inhibitors due to its reactive sulfonyl chloride group.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences sector, enabling the production of bespoke molecules for client R&D.

Basic Information

Product Name	4-Fluoronaphthalene-1-Sulfonyl Chloride
CAS No.	316-69-8
Molecular Formula	C₁₀H₆ClFO₂S
Molecular Weight	244.67 g/mol
Synonyms	1-Fluoro-4-naphthalenesulfonyl chloride; 4-Fluoro-1-naphthalenesulfonyl chloride; 1-Naphthalenesulfonyl chloride, 4-fluoro-; 4-Fluoronaphthalene-1-sulphonyl chloride; 4-Fluoro-1-naphthalenesulphonyl chloride; NSC 403119; 4-Fluoronaphthalenesulfonyl chloride
EINECS	206-267-7

Quality Control

Our 4-Fluoronaphthalene-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0 - 103.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.