Description

Norcyclobenzaprine CAS NO 303-50-4 is a pharmaceutical intermediate and a structural analog of cyclobenzaprine, a centrally-acting muscle relaxant. This compound is of significant value in the research and development of new therapeutic agents targeting muscle spasms and related neurological conditions. It serves as a critical building block for medicinal chemists and is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic research institutions focused on neuropharmacology.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel muscle relaxant compounds and their derivatives.
• Medicinal Chemistry Research: Used as a reference standard or starting material for structure-activity relationship (SAR) studies.
• Active Pharmaceutical Ingredient (API) Development: Employed in the development and scale-up processes for potential new drug candidates.
• Analytical Standard: Serves as a high-purity standard for method development and quality control in analytical laboratories (HPLC, GC-MS).
• Biochemical Research: Used in *in vitro* studies to investigate mechanisms of action related to skeletal muscle tone.

Basic Information

Product Name	Norcyclobenzaprine
CAS No.	303-50-4
Molecular Formula	C20H21N
Molecular Weight	275.39 g/mol
Synonyms	10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one, 3-(methylamino)propylidene derivative; 3-((10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)methyl)(methyl)amine; Desmethylcyclobenzaprine; Norcyclobenzaprine HCl; NSC 169865; Cyclobenzaprine Impurity; Cyclobenzaprine Related Compound A
EINECS	Contact for details

Quality Control

Our Norcyclobenzaprine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and GC-MS, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.