Description

Heliotrine is a pyrrolizidine alkaloid (PA) of significant interest in research and development due to its specific biological activity. This compound is crucial for scientists and manufacturers requiring high-purity reference standards for analytical and toxicological studies. It is primarily utilized by the pharmaceutical, biotechnology, and agrochemical industries for method development, quality control, and safety assessment programs.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of pyrrolizidine alkaloids in herbal medicines, supplements, and food products.
• Toxicology Research: Serves as a key analyte in studies investigating the hepatotoxic and carcinogenic mechanisms of pyrrolizidine alkaloids.
• Analytical Method Development: Essential for developing and validating sensitive analytical methods, such as LC-MS/MS and HPLC, for PA detection in complex matrices.
• Quality Control & Safety Testing: Employed by quality assurance laboratories to test raw materials and finished products for the presence of regulated toxic alkaloids.
• Biochemical Research: Used in studies exploring the biosynthesis, metabolism, and biological pathways of plant-derived alkaloids.
• Agrochemical Analysis: Applied in monitoring PA levels in forage, honey, and other agricultural commodities to ensure safety and compliance.

Basic Information

Product Name	Heliotrine
CAS No.	303-33-3
Molecular Formula	C16H27NO5
Molecular Weight	313.39 g/mol
Synonyms	Heliotrine; (+)-Heliotrine; (3R,5R,8R)-3-[(S)-1-Hydroxyethyl]-8-[(S)-1-methoxyethyl]-1-methylpyrrolizidine-3,5-diol; 3,5-Dihydroxy-3,5-bis(1-hydroxyethyl)-1-methylpyrrolizidinium-8-carboxylic acid γ-lactone; NSC 25247; Laslocarpine N-oxide (related isomer)
EINECS	Contact for details

Quality Control

Our Heliotrine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We support compliance with relevant pharmacopeial and ISO guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.