Description

Parp1-In-5 (Dihydrochloride) is a potent and selective small-molecule inhibitor of the poly(ADP-ribose) polymerase 1 (PARP1) enzyme. This compound is a critical research tool for investigating DNA damage response pathways and synthetic lethality in oncology research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel cancer therapeutics and understanding cellular repair mechanisms.

Application

• Oncology Research & Drug Discovery: A key biochemical tool for studying PARP1 inhibition, DNA repair mechanisms, and synthetic lethality, particularly in BRCA-deficient cancer models.
• Biochemical Assay Development: Used as a reference standard and active control in high-throughput screening (HTS) assays to identify and validate new PARP inhibitors.
• Mechanistic & Cellular Studies: Enables investigation of PARP1's role in various cellular processes including inflammation, neurodegeneration, and ischemia-reperfusion injury.
• Preclinical Pharmacology: Supports in vitro and in vivo studies to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of PARP-targeted therapies.
• Chemical Biology & Proteomics: Serves as a molecular probe to map PARP1 interactions and downstream signaling pathways using techniques like chemoproteomics.

Basic Information

Product Name	Parp1-In-5 (Dihydrochloride)
CAS No.	2823308-89-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PARP1-IN-5 dihydrochloride; PARP1 Inhibitor 5 (dihydrochloride); 2-[[4-[(3S)-3-Methyl-4-(1,3,4-oxadiazol-2-ylcarbonyl)piperazin-1-yl]phenyl]amino]-1,3-benzothiazole-6-carboxamide dihydrochloride; (S)-2-((4-(3-methyl-4-(1,3,4-oxadiazole-2-carbonyl)piperazin-1-yl)phenyl)amino)benzo[d]thiazole-6-carboxamide dihydrochloride
EINECS	Contact for details

Quality Control

Our Parp1-In-5 (Dihydrochloride) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This material is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.