Description

Tgfβri-In-3 CAS NO 2763602-67-9 is a potent and selective small molecule inhibitor targeting the Transforming Growth Factor Beta Receptor I (TGFβRI/ALK5). This compound is a critical research tool for modulating the TGF-β signaling pathway, which plays a central role in cellular processes such as proliferation, differentiation, and apoptosis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology, fibrosis, and immunology research to investigate disease mechanisms and develop novel therapeutic strategies.

Application

• Biomedical Research: Used as a key pharmacological probe to selectively inhibit TGFβRI/ALK5 kinase activity in in vitro and in vivo studies.
• Oncology Research: Investigates the role of TGF-β signaling in tumor progression, metastasis, and the tumor microenvironment.
• Fibrosis Disease Models: Applied in research models for pulmonary, hepatic, and renal fibrosis to assess anti-fibrotic effects.
• Immunology Studies: Explores the modulation of T-cell differentiation and function by the TGF-β pathway.
• Stem Cell Research: Utilized to control differentiation pathways in pluripotent and mesenchymal stem cells.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in assay development and drug discovery campaigns.
• Mechanistic Studies: Elucidates downstream signaling events (Smad2/3 phosphorylation) and pathway crosstalk.

Basic Information

Product Name	Tgfβri-In-3
CAS No.	2763602-67-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	TGFβRI-IN-3; TGFβRI Inhibitor 3; ALK5 Inhibitor 3; TGF-beta receptor I inhibitor 3; 2763602-67-9; Tgfβri-In-3; Transforming Growth Factor Beta Receptor I Inhibitor 3
EINECS	Contact for details

Quality Control

Our Tgfβri-In-3 is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.