Description

Cdk5-In-3 CAS NO 2639542-32-6 is a potent and selective small-molecule inhibitor of cyclin-dependent kinase 5 (CDK5), a key regulatory protein involved in neuronal signaling and cell cycle progression. This high-purity compound is essential for biochemical and pharmacological research, enabling the study of neurodegenerative diseases, neurodevelopmental disorders, and cancer biology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutic agents.

Application

• Neuroscience Research: Used as a critical tool compound to investigate CDK5's role in neuronal function, synaptic plasticity, and neurodegenerative pathways associated with Alzheimer's and Parkinson's disease.
• Oncology Studies: Employed in cancer research to explore the non-neuronal functions of CDK5 in tumor cell proliferation, migration, and survival across various cancer types.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in high-throughput screening (HTS) and structure-activity relationship (SAR) studies for novel CDK5 inhibitors.
• Biochemical Assay Development: Utilized to establish and validate in vitro kinase inhibition assays to measure CDK5 activity and selectivity.
• Cellular Mechanism Studies: Applied in cell-based models to dissect signaling cascades and downstream effects of CDK5 inhibition.
• Academic & Contract Research: A fundamental reagent for basic scientific research in university laboratories and contract research organizations (CROs).

Basic Information

Product Name	Cdk5-In-3
CAS No.	2639542-32-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CDK5-IN-3; Cdk5 Inhibitor 3; Cyclin-Dependent Kinase 5 Inhibitor 3; 2639542-32-6; CDK5i-3; CDK5 Inhibitor Compound 3
EINECS	Contact for details

Quality Control

Our Cdk5-In-3 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR/MS for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and analytical data is provided with every shipment to support your research integrity and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a desiccator to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.