Description

5H-Pyrrolo[3,4-B]Pyridine, 3-Fluoro-6,7-Dihydro-, Hydrochloride (1:2) is a high-purity, advanced pharmaceutical intermediate with a defined dihydrochloride salt form. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic entities.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of complex, fluorinated heterocyclic APIs.
• Oncology Drug Discovery: The pyrrolopyridine scaffold is of significant interest for developing kinase inhibitors and other targeted cancer therapies.
• CNS Drug Development: Applied in the research of neurological and psychiatric disorders due to the privileged structure of its core.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic and heterocyclic chemistry.

Basic Information

Product Name	5H-Pyrrolo[3,4-B]Pyridine, 3-Fluoro-6,7-Dihydro-, Hydrochloride (1:2)
CAS No.	2613381-76-1
Molecular Formula	C7H7FN2 • 2HCl
Molecular Weight	223.06 g/mol (Free base) / 296.00 g/mol (Dihydrochloride Salt)
Synonyms	3-Fluoro-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine dihydrochloride; 3-Fluoro-5,7-dihydropyrrolo[3,4-b]pyridine dihydrochloride; 3-Fluoro-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride (1:2); 3-Fluoro-5H-pyrrolo[3,4-b]pyridine, 6,7-dihydro-, dihydrochloride; 3-Fluoro-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine 2HCl; CAS 2613381-76-1
EINECS	Contact for details

Quality Control

Our 5H-Pyrrolo[3,4-B]Pyridine, 3-Fluoro-6,7-Dihydro-, Hydrochloride (1:2) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.