Description

Dhodh-In-16 is a high-purity, small molecule inhibitor specifically targeting the dihydroorotate dehydrogenase (DHODH) enzyme. This compound is of significant value in pharmaceutical research and development, particularly for its role in modulating cellular metabolism and immune response pathways. It is primarily utilized by researchers and developers in the life sciences sector, including those working in oncology, autoimmune disease research, and antiviral drug discovery. The product is supplied under strict quality control to ensure batch-to-batch consistency for critical experimental and developmental work.

Application

• Pharmaceutical R&D: Acts as a key biochemical tool and reference standard in the discovery and development of novel DHODH inhibitors for therapeutic applications.
• Oncology Research: Investigated for its potential to inhibit cancer cell proliferation by interfering with pyrimidine biosynthesis, a pathway critical for rapidly dividing cells.
• Immunology & Autoimmune Disease Studies: Used to study the modulation of T-cell and B-cell activation, relevant for conditions like rheumatoid arthritis, multiple sclerosis, and lupus.
• Antiviral Agent Development: Explored for its ability to inhibit replication of certain viruses that are dependent on host cell pyrimidine pools.
• Biochemical Assay Development: Serves as a potent inhibitor in enzymatic assays to study DHODH kinetics, mechanism of action, and for high-throughput screening campaigns.
• Cell Biology & Metabolic Studies: A critical reagent for probing the link between mitochondrial metabolism, nucleotide synthesis, and cellular function.

Basic Information

Product Name	Dhodh-In-16
CAS No.	2511248-11-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	DHODH Inhibitor 16; Dihydroorotate Dehydrogenase Inhibitor 16; 2511248-11-4; Lead compound for DHODH inhibition; Small molecule DHODH antagonist; Pyrimidine synthesis inhibitor 16; Research compound 2511248-11-4
EINECS	Contact for details

Quality Control

Every batch of Dhodh-In-16 is manufactured and analyzed under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards and precise activity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency is provided with each shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. The container should be kept in a well-ventilated area designated for research chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (IC50)	Reported per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.