Description

Protac Krasg12C Degrader-Lc-2 CAS NO 2502156-03-6 is a high-purity, bifunctional small molecule degrader designed for targeted protein degradation (TPD) research. This compound is a critical tool for investigating KRAS G12C mutant signaling pathways and developing novel therapeutic strategies in oncology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on precision medicine and cancer drug discovery.

Application

• Targeted Protein Degradation (TPD) Research: Serves as a key chemical probe for studying PROTAC (Proteolysis Targeting Chimera) technology and ubiquitin-proteasome system (UPS) mechanisms.
• Oncology & Cancer Biology Studies: Specifically designed for the selective degradation of the KRAS G12C mutant protein, a prevalent oncogenic driver in various cancers.
• Drug Discovery & Preclinical Development: Used in hit-to-lead optimization, proof-of-concept studies, and the development of novel degrader-based therapeutics.
• Mechanism of Action (MOA) Analysis: Enables researchers to validate drug targets, understand downstream signaling consequences of protein degradation, and identify potential resistance mechanisms.
• Biochemical & Cellular Assay Development: Acts as a reference standard or active component in high-throughput screening (HTS) and functional cellular assays.

Basic Information

Product Name	Protac Krasg12C Degrader-Lc-2
CAS No.	2502156-03-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	KRAS G12C Degrader Lc-2; PROTAC KRAS G12C Degrader; KRAS(G12C) PROTAC; KRAS G12C Targeted Degrader; Degrader of KRAS G12C; Protein Degrader for KRAS G12C; Bifunctional KRAS Degrader; TPD Compound for KRAS Mutant
EINECS	Contact for details

Quality Control

Our Protac Krasg12C Degrader-Lc-2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, LC-MS, and NMR, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.