Description

Brd7 Inhibitor 1 CAS NO 2448414-48-8 is a potent and selective small molecule inhibitor of the Bromodomain-containing protein 7 (BRD7), a key epigenetic reader protein. This compound matters for researchers as it provides a precise chemical tool to modulate BRD7 function, enabling the study of chromatin remodeling, transcriptional regulation, and associated disease pathways. It is primarily needed by pharmaceutical R&D teams and academic laboratories focused on oncology, neurodegenerative diseases, and fundamental epigenetic mechanisms.

Application

• Epigenetics Research: Used as a selective chemical probe to investigate the biological role and signaling pathways of the BRD7 bromodomain in cellular models.
• Oncology Target Validation: Employed in in vitro and in vivo studies to assess BRD7 as a potential therapeutic target in various cancers.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) campaigns and binding assays (e.g., TR-FRET, AlphaScreen).
• Mechanism of Action Studies: Utilized to elucidate the functional consequences of BRD7 inhibition on gene expression profiles and protein-protein interactions.
• Neurodegenerative Disease Research: Applied in preclinical research to explore the involvement of epigenetic readers like BRD7 in conditions such as Alzheimer's disease.
• Chemical Biology Tool Compound: Integral for structure-activity relationship (SAR) studies to design next-generation bromodomain inhibitors.

Basic Information

Product Name	Brd7 Inhibitor 1
CAS No.	2448414-48-8
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	BRD7 Inhibitor 1; BRD7 Inhibitor; 2448414-48-8; N-[4-(2,4-Difluorophenoxy)-3-methoxyphenyl]-4-(4-methylpiperazin-1-yl)pyrimidin-2-amine; BRD7i-1; BRD7 Bromodomain Inhibitor; Chemical probe for BRD7; BRD7 inhibitor compound 1
EINECS	Contact for details

Quality Control

Our Brd7 Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure high chemical integrity and batch-to-batch consistency suitable for research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.