Description

Camonsertib is a potent and selective small molecule inhibitor targeting the ATR kinase, a key component of the DNA damage response pathway. This compound is of significant interest for its potential in oncology research, particularly in synthetic lethality strategies for cancers with specific genomic vulnerabilities. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs engaged in the discovery and development of novel cancer therapeutics. The product is supplied under the identifier CAS 2417489-10-0.

Application

• Oncology Research & Drug Discovery: As a critical tool compound for investigating the ATR signaling pathway and its role in DNA repair mechanisms.
• Preclinical Development: For in vitro and in vivo efficacy and safety studies to support Investigational New Drug (IND) applications.
• Biomarker & Combination Therapy Studies: To explore predictive biomarkers of response and synergistic effects with other anticancer agents like PARP inhibitors or chemotherapy.
• Chemical Biology & Target Validation: Used to elucidate the biological functions of ATR and validate it as a therapeutic target in various cancer models.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in pharmaceutical manufacturing.
• Synthetic Lethality Screens: Employed in high-throughput screening to identify cancer cell lines with specific genetic alterations (e.g., ATM deficiency) that are hypersensitive to ATR inhibition.

Basic Information

Product Name	Camonsertib
CAS No.	2417489-10-0
Molecular Formula	C₂₄H₂₈N₈O₃
Molecular Weight	476.54 g/mol
Synonyms	RP-3500; ATR Inhibitor RP-3500; Camonsertib (RP-3500); (S)-2-(4-((4-(3-(2-Amino-2-oxoacetamido)pyridin-2-yl)phenyl)amino)-5-fluoro-2-oxopyrimidin-1(2H)-yl)-N-methyl-2-phenylacetamide; AZD-6738 analog; ATR kinase inhibitor
EINECS	Contact for details

Quality Control

Our Camonsertib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We support compliance with relevant guidelines for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed tightly after each use to minimize exposure to ambient humidity. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.