Description

Mono Oxidation Sugammadex (Org198958-2) is a key intermediate in the synthesis of Sugammadex, a modified γ-cyclodextrin used as a selective relaxant binding agent. This compound matters for its critical role in ensuring the purity and efficacy of the final active pharmaceutical ingredient (API). Pharmaceutical manufacturers and advanced research facilities require this high-purity intermediate for the development and production of neuromuscular blockade reversal agents. Its precise chemical structure, identified by CAS No. 2412953-13-8, is essential for consistent batch-to-batch performance.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Primary use in the synthesis of Sugammadex sodium.
• Pharmaceutical Research & Development: Serves as a critical reference standard and building block in preclinical and clinical studies.
• Process Chemistry & Scale-Up: Used in optimizing manufacturing routes for neuromuscular reversal drugs.
• Quality Control & Analytical Testing: Employed as an impurity marker or standard in HPLC and LC-MS methods for Sugammadex batch analysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) specializing in sterile injectables.

Basic Information

Item	Detail
Product Name	Mono Oxidation Sugammadex (Org198958-2)
CAS No.	2412953-13-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Org 198958-2; 6-Per-(6-carboxy-6-mercapto-3-oxapropylthio)-γ-cyclodextrin mono-oxide; Sugammadex Oxidation Impurity; Sugammadex Intermediate; 6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-[2-(carboxymethoxy)ethyl]-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin S-oxide
EINECS	Contact for details

Quality Control

Our Mono Oxidation Sugammadex (Org198958-2) is manufactured under strict quality systems suitable for pharmaceutical intermediates. Each batch undergoes rigorous analytical testing, including HPLC purity assay and identity confirmation (IR, MS), to ensure it meets stringent specifications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results against release criteria. We support compliance with ICH Q7 guidelines and can provide documentation for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Keep the container in a dry, well-ventilated place. For long-term storage, consider conditions under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0% w/w
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.