Description

Protac Brd4 Degrader-5 is a potent and selective small-molecule degrader designed to target the Bromodomain-containing protein 4 (BRD4) via proteolysis-targeting chimera (PROTAC) technology. This compound matters for researchers as it offers a powerful chemical tool for investigating BRD4 biology, protein degradation pathways, and potential therapeutic strategies in oncology and other disease areas. It is primarily needed by pharmaceutical R&D teams, academic research laboratories, and biotechnology companies focused on targeted protein degradation, epigenetics, and drug discovery.

Application

• Biomedical Research: A critical chemical probe for studying BRD4 function, chromatin remodeling, and gene transcription in cellular and in vitro models.
• Drug Discovery & Development: Used in hit-to-lead optimization and proof-of-concept studies for novel PROTAC-based therapeutics targeting oncoproteins.
• Mechanistic Studies: Enables investigation of the ubiquitin-proteasome system (UPS), ternary complex formation, and kinetics of targeted protein degradation.
• Preclinical Validation: Supports target validation and efficacy testing in disease-relevant cell lines and animal models for cancers driven by BRD4.
• Comparative Analysis: Serves as a reference compound for evaluating the potency and selectivity of new BRD4-targeting PROTAC degraders.

Basic Information

Product Name	Protac Brd4 Degrader-5
CAS No.	2409538-70-9
Molecular Formula	C41H50ClN7O6S
Molecular Weight	828.40 g/mol
Synonyms	PROTAC BRD4 Degrader-5; BRD4 Degrader-5; ARV-825 analog; (S,R,S)-AHPC-based BRD4 degrader; dBET6; MZ1 analog; BET protein degrader; Chemical degrader of BRD4; PROTAC targeting BRD4 and VHL
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Protac Brd4 Degrader-5 is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request to support your research documentation and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.