Description

Bempedoic Acid-D4 CAS NO 2408131-70-2 is a high-purity, deuterium-labeled analog of the active pharmaceutical ingredient bempedoic acid. This stable isotope-labeled compound is an essential tool for quantitative bioanalytical studies, enabling precise pharmacokinetic and metabolic profiling. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and regulatory submission support for lipid-lowering therapies.

Application

• Use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the accurate quantification of bempedoic acid in biological matrices.
• Facilitate drug metabolism and pharmacokinetics (DMPK) studies, including absorption, distribution, metabolism, and excretion (ADME) profiling.
• Support clinical trial bioanalysis to ensure reliable and GLP/GCP-compliant data for regulatory filings with agencies like the FDA and EMA.
• Enable metabolite identification and pathway elucidation studies using advanced mass spectrometry techniques.
• Serve as a critical reference material in method development and validation for quality control laboratories.
• Application in isotope dilution analysis to achieve superior accuracy and precision over conventional analytical methods.

Basic Information

Product Name	Bempedoic Acid-D4
CAS No.	2408131-70-2
Molecular Formula	C19H20D4O6
Molecular Weight	360.41 g/mol (approx.)
Synonyms	8-Hydroxy-2,2,14,14-tetradeutero-14-oxotetradecanedioic Acid; ETC-1002-d4; ESP55016-d4; (8R,9S,13S,14S)-13-Methyl-6,7,8,9,11,12,13,14,15,16-decahydro-17H-cyclopenta[a]phenanthrene-3,17-diol-d4; Deuterated Bempedoic Acid; Bempedoic Acid (tetradeutero); Stable Isotope-Labeled Bempedoic Acid
EINECS	Contact for details

Quality Control

Our Bempedoic Acid-D4 is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by MS), and residual solvent content. We support GLP/GMP-compliant research and can provide materials suitable for use as certified reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.