Description

Benzenesulfonyl Fluoride, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- CAS NO 2393030-89-0 is a high-value, multi-functional organoboron building block featuring a sulfonyl fluoride handle. This compound matters for its unique dual reactivity, enabling Suzuki-Miyaura cross-coupling via the boronate ester and selective, irreversible SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry via the sulfonyl fluoride group. It is primarily needed by medicinal chemistry and process R&D teams in the pharmaceutical and agrochemical industries for the efficient synthesis of complex molecules, including potential drug candidates and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of bioactive molecules and potential active pharmaceutical ingredients (APIs) via sequential cross-coupling and bioconjugation strategies.
• SuFEx Click Chemistry: Enables rapid, reliable, and modular construction of sulfonate ester and sulfonamide linkages for applications in chemical biology, polymer science, and materials development.
• Medicinal Chemistry & Drug Discovery: Used in library synthesis for creating diverse compound arrays to explore structure-activity relationships (SAR) and identify new lead compounds.
• Agrochemical Research: Serves as a versatile intermediate in the development of novel herbicides, fungicides, and insecticides with tailored properties.
• Material Science: Facilitates the creation of novel polymers and functional materials with specific chemical and physical properties through controlled chemical modification.
• Bioconjugation & Probe Development: The sulfonyl fluoride group allows for selective labeling of proteins, enzymes, and other biomolecules for diagnostic and research applications.

Basic Information

Product Name	Benzenesulfonyl Fluoride, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	2393030-89-0
Molecular Formula	C12H16BFO4S
Molecular Weight	286.13 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl fluoride; (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl fluoride; 3-Boronic acid, benzenesulfonyl fluoride, pinacol ester; 3-(Pinacolatoboryl)benzenesulfonyl fluoride; m-(Pinacolatoboryl)benzenesulfonyl fluoride; 3-Sulfonylfluoridephenylboronic acid pinacol ester; Benzene-1,3-disulfonyl fluoride boronic ester
EINECS	Contact for details

Quality Control

Our production of Benzenesulfonyl Fluoride, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your critical research and development. Each lot undergoes comprehensive analytical characterization, including NMR (1H, 13C, 19F, 11B) and HPLC purity analysis. A detailed Certificate of Analysis (COA) providing full specifications is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.