Description

Sgk3 Degrader-1 is a potent and selective small molecule degrader targeting Serum/Glucocorticoid Regulated Kinase 3 (SGK3). This compound is a critical research tool for investigating the role of SGK3 in cellular signaling pathways, particularly those related to cell survival, proliferation, and oncogenesis. It is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, metabolic disorders, and kinase biology. The product is supplied with a high level of purity and batch-to-batch consistency to ensure reliable experimental results.

Application

• Biochemical Research: Used as a selective molecular probe to study SGK3 function and validate its role in specific disease pathways.
• Drug Discovery & Development: Serves as a lead compound or tool molecule in the development of novel targeted protein degradation (TPD) therapies.
• Oncology Research: Investigates the therapeutic potential of SGK3 degradation in various cancer models, including breast, prostate, and other malignancies where SGK3 is implicated.
• Signal Transduction Studies: Elucidates downstream effects of SGK3 inhibition on key cellular processes like apoptosis and metabolism.
• Mechanism of Action (MoA) Studies: Helps in understanding the kinetics and specificity of PROTAC-mediated degradation for SGK3.
• Preclinical Validation: Supports in vitro and in vivo studies to assess the efficacy and pharmacodynamics of SGK3-targeting strategies.

Basic Information

Product Name	Sgk3 Degrader-1
CAS No.	2381320-35-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	SGK3 Degrader-1; SGK3 PROTAC; SGK3-targeting Degrader; CAS 2381320-35-8; (Chemical name based on structure to be confirmed); Potential research code names may apply.
EINECS	Contact for details

Quality Control

Our Sgk3 Degrader-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results for purity, potency, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.