Description

Cdk4/6-In-6 CAS NO 2380321-51-5 is a potent and selective small-molecule inhibitor targeting the cyclin-dependent kinases 4 and 6 (CDK4/6), key regulators of the cell cycle. This compound is of significant value for research into cell proliferation mechanisms and the development of novel therapeutic strategies, particularly in oncology. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer biology and drug discovery.

Application

• Biochemical Research: Used as a critical tool compound to study the G1/S cell cycle checkpoint and the role of CDK4/6 in cellular proliferation and senescence.
• Drug Discovery & Development: Serves as a lead compound or reference standard in the screening and optimization of novel CDK4/6 inhibitors for cancer therapy.
• Mechanism of Action Studies: Employed in vitro and in vivo to elucidate signaling pathways downstream of CDK4/6 and to validate therapeutic targets.
• Preclinical Cancer Models: Utilized in animal studies to evaluate the efficacy and pharmacokinetics of CDK4/6 inhibition against various tumor types.
• High-Content Screening (HCS): Acts as a control or probe in automated cellular imaging assays to quantify cell cycle arrest and other phenotypic changes.

Basic Information

Item	Details
Product Name	Cdk4/6-In-6
CAS No.	2380321-51-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CDK4/6-IN-6; Cdk4/6 Inhibitor 6; 2380321-51-5; Cyclin-Dependent Kinase 4/6 Inhibitor 6; CDK4/6-IN6; CDK4/6 inhibitor compound 6; Potential CDK4 and CDK6 inhibitor
EINECS	Contact for details

Quality Control

Our Cdk4/6-In-6 is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity, essential for reliable research data. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectral confirmation (NMR, MS) for structural identity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.