Description

Protac K-Ras Degrader-1 is a potent and selective bifunctional degrader molecule designed for targeted protein degradation (TPD) research. This compound is a critical tool for investigating novel therapeutic strategies against cancers driven by notoriously difficult-to-drug K-Ras mutations. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on oncology and proteolysis-targeting chimera (PROTAC) technology development.

Application

• PROTAC & Targeted Protein Degradation (TPD) Research: Serves as a key chemical probe to study the degradation of oncogenic K-Ras mutants (e.g., G12C, G12D, G12V) via the ubiquitin-proteasome system.
• Oncology Drug Discovery: Used in preclinical studies to validate K-Ras as a therapeutic target and to explore the efficacy of degradation versus inhibition.
• Mechanism of Action (MoA) Studies: Enables investigation into ternary complex formation, ubiquitination kinetics, and downstream signaling consequences of K-Ras removal.
• Biochemical & Cellular Assay Development: Acts as a reference standard in high-throughput screening (HTS) and functional assays to identify and optimize novel degrader compounds.
• Chemical Biology Tool: Used to elucidate the roles of specific K-Ras isoforms and mutants in cellular proliferation, survival, and tumorigenesis.
• Lead Compound Optimization: Provides a structural scaffold for medicinal chemistry efforts aimed at improving degradation potency, selectivity, and drug-like properties.

Basic Information

Product Name	Protac K-Ras Degrader-1
CAS No.	2378258-52-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	KRAS Degrader-1; K-Ras PROTAC Degrader 1; PROTAC KRAS Degrader 1; (S,R,S)-AHPC-Me-2,6-dichloro-4-((4-(4-methylpiperazin-1-yl)phenyl)amino)quinazoline-6-C2-NH2 hydrochloride; KRAS(PROTAC)-1; LC-2; Targeted KRAS Degrader
EINECS	Contact for details

Quality Control

Our Protac K-Ras Degrader-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes rigorous analytical characterization, including purity verification by HPLC and structural confirmation by NMR and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.