Description

Mrgprx1 Agonist 1 is a potent and selective small-molecule agonist targeting the Mas-related G-protein coupled receptor X1 (MrgprX1). This compound is of significant value for research into neurogenic inflammation, pruritus (itch), and pain signaling pathways. It is an essential pharmacological tool for academic, biotechnology, and pharmaceutical R&D teams focused on developing novel therapeutics for chronic pain and dermatological conditions. The product is supplied under the CAS registry number 2377379-39-8.

Application

• Neuroscience Research: Used as a selective probe to study the role of MrgprX1 in sensory neuron signaling and neuropeptide release.
• Drug Discovery & Development: Serves as a reference compound and positive control in high-throughput screening (HTS) campaigns and lead optimization for novel analgesic or anti-pruritic agents.
• In Vitro Pharmacology: Functional characterization of MrgprX1 receptor activity in cell-based assays (e.g., calcium flux, cAMP, β-arrestin recruitment).
• Preclinical Studies: Investigation of itch and pain mechanisms in animal models to validate target biology and therapeutic potential.
• Biomarker Research: Exploring the connection between MrgprX1 activation and specific disease states or inflammatory markers.

Basic Information

Product Name	Mrgprx1 Agonist 1
CAS No.	2377379-39-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	MRGPRX1 Agonist 1; Mas-related G-protein coupled receptor X1 Agonist 1; MrgprX1 agonist; 2377379-39-8; AG-205; AG 205; AG205; (Compound name based on internal R&D code)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Mrgprx1 Agonist 1 is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing batch-specific results for purity, residual solvents, and other critical parameters are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storing under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.