Description

K-Ras G12C-In-4 is a potent and selective small molecule inhibitor targeting the oncogenic KRAS G12C mutant protein. This compound is a critical research tool for investigating targeted cancer therapies and the role of KRAS signaling in tumorigenesis. It is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel oncology treatments and conducting mechanistic studies in cancer biology.

Application

• Biochemical Research: Used as a reference standard and active compound in in vitro assays to study KRAS G12C inhibition kinetics and signaling pathway disruption.
• Drug Discovery & Development: Serves as a key intermediate or pharmacophore model for the design and synthesis of next-generation KRAS G12C inhibitors.
• Cellular & Molecular Biology: Applied in cell-based studies to evaluate the effects of KRAS pathway inhibition on cancer cell proliferation, apoptosis, and migration.
• Preclinical Studies: Utilized in animal models to assess the pharmacokinetics, efficacy, and safety profiles of potential anti-cancer drug candidates.
• High-Throughput Screening (HTS): Employed as a control compound in screening campaigns to identify novel modulators of the KRAS pathway.
• Mechanism of Action (MoA) Studies: Critical for elucidating the precise binding mode and downstream consequences of KRAS G12C inhibition.

Basic Information

Product Name	K-Ras G12C-In-4
CAS No.	2376328-55-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	KRAS G12C-IN-4; K-Ras G12C Inhibitor 4; G12C-IN-4; 2376328-55-9; KRAS(G12C) inhibitor 4; (S)-1-(4-(7-(2-(2,6-Dichloro-3,5-dimethoxyphenyl)ethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl)-3-(1-methyl-1H-pyrazol-4-yl)propan-1-ol (IUPAC name to be confirmed); G12C Inhibitor-4
EINECS	Contact for details

Quality Control

Our K-Ras G12C-In-4 is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.