Description

Protac Parp1 Degrader CAS NO 2369022-68-2 is a potent and selective small-molecule degrader designed for targeted protein degradation (TPD) research, specifically targeting the PARP1 enzyme. This compound is a critical tool for investigating novel therapeutic strategies in oncology, particularly for cancers with DNA repair deficiencies. It is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing next-generation cancer therapies and exploring the mechanisms of proteolysis-targeting chimeras (PROTACs).

Application

• Targeted Protein Degradation (TPD) Research: A key chemical probe for studying PROTAC-mediated degradation mechanisms and kinetics.
• Oncology Drug Discovery: Used in preclinical studies to validate PARP1 as a therapeutic target and to explore synthetic lethality in cancer models.
• Biochemical Assay Development: Serves as a reference standard in developing high-throughput screening assays for degrader activity.
• Mechanism of Action Studies: Enables research into the ubiquitin-proteasome system (UPS) and the consequences of PARP1 loss-of-function in cells.
• Academic Research: Fundamental tool for universities and research institutes exploring novel pathways in DNA damage response and repair.
• Combination Therapy Research: Investigated for potential synergistic effects with other chemotherapeutic agents or radiotherapy.

Basic Information

Product Name	Protac Parp1 Degrader
CAS No.	2369022-68-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC PARP1 degrader; PARP1 PROTAC; PARP1 Degrader; PARP1-targeting PROTAC; Proteolysis Targeting Chimera for PARP1; (S,R,S)-AHPC-PEG4-VH032-PARP1 ligand conjugate; Degrader of Poly [ADP-ribose] polymerase 1
EINECS	Contact for details

Quality Control

Our Protac Parp1 Degrader is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and strength is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. Store away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.