Description

Protac B-Raf Degrader 1 is a potent and selective small-molecule degrader designed for targeted protein degradation research. This compound is a critical tool for investigating novel therapeutic strategies in oncology by specifically inducing the degradation of the B-Raf protein, a key driver in several cancers. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on advancing targeted cancer therapies and PROTAC (Proteolysis Targeting Chimera) technology.

Application

• PROTAC Mechanism of Action (MoA) Studies: Fundamental research into the kinetics, efficiency, and specificity of targeted protein degradation.
• Oncology Drug Discovery: Pre-clinical investigation of B-Raf as a therapeutic target in melanoma, colorectal cancer, and other malignancies.
• Signal Transduction Pathway Analysis: Used to dissect the role of B-Raf in the MAPK/ERK signaling pathway and study pathway dependencies.
• Resistance Mechanism Research: Exploring and overcoming resistance to traditional B-Raf kinase inhibitors.
• Biochemical Assay Development: Serving as a reference standard in cellular and biochemical assays for degrader activity.
• Chemical Biology Tool: A precise molecular probe for studying protein function, ubiquitin-proteasome system engagement, and cellular protein homeostasis.

Basic Information

Product Name	Protac B-Raf Degrader 1
CAS No.	2364367-27-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC B-Raf Degrader 1; B-Raf PROTAC Degrader 1; B-Raf Degrader; B-Raf Protein Degrader; PROTAC B-Raf ligand; B-Raf targeting PROTAC; (S,R,S)-AHPC-Me-Br degrader of B-Raf; ARS-1620-based PROTAC
EINECS	Contact for details

Quality Control

Our Protac B-Raf Degrader 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for reproducible research outcomes. All batches are accompanied by comprehensive analytical data including HPLC, NMR, and MS. Certificates of Analysis (COA) are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability and potency. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.