Description

Stat3-In-3 CAS NO 2361304-26-7 is a potent and selective small molecule inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3) protein. This compound matters significantly as it directly targets a key oncogenic signaling pathway implicated in tumor proliferation, survival, and immune evasion. It is primarily needed by researchers in pharmaceutical R&D and academic institutions focused on developing novel cancer therapeutics and studying STAT3 biology in various disease models.

Application

• Oncology Research & Drug Discovery: A critical tool compound for studying the role of STAT3 signaling in cancer cell lines and animal models, facilitating target validation and lead optimization.
• Biochemical & Cellular Assay Development: Used as a reference standard in high-throughput screening (HTS) campaigns to identify new STAT3 pathway modulators.
• Mechanistic Studies: Enables detailed investigation of STAT3's function in inflammation, autoimmune diseases, and other pathological conditions beyond oncology.
• Preclinical Proof-of-Concept: Supports in vivo efficacy studies to evaluate the therapeutic potential of STAT3 inhibition for specific cancer types.
• Combination Therapy Research: Explored in conjunction with other targeted agents or immunotherapies to overcome drug resistance and enhance anti-tumor efficacy.

Basic Information

Product Name	Stat3-In-3
CAS No.	2361304-26-7
Molecular Formula	C₂₀H₁₇N₅O₂S
Molecular Weight	391.45 g/mol
Synonyms	STAT3-IN-3; STAT3 Inhibitor, STAT3-In-3; 2361304-26-7; N-(4-((2-((2-(Dimethylamino)ethyl)amino)-4-pyrimidinyl)oxy)phenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide; 4-Methyl-N-[4-({2-[(2-methylaminoethyl)amino]pyrimidin-4-yl}oxy)phenyl]-1,2,3-thiadiazole-5-carboxamide
EINECS	Contact for details

Quality Control

Our Stat3-In-3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and NMR/LC-MS for structural identity, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under desiccated conditions. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.