Description

Protac Irak4 Degrader-1 is a potent and selective small-molecule degrader designed to target the IRAK4 protein via the PROTAC (Proteolysis-Targeting Chimera) mechanism. This compound is a critical research tool for investigating novel therapeutic strategies in oncology and inflammatory diseases by inducing the ubiquitination and subsequent proteasomal degradation of its target. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on targeted protein degradation, kinase signaling pathways, and drug discovery for conditions like lymphoma and autoimmune disorders.

Application

• Targeted Protein Degradation Research: A key tool for validating the PROTAC platform and studying the pharmacological consequences of IRAK4 knockdown.
• Oncology Drug Discovery: Used in preclinical studies to evaluate the therapeutic potential of IRAK4 degradation in hematological cancers and solid tumors.
• Immunology and Inflammation Research: Facilitates the study of IRAK4's role in TLR/IL-1R signaling pathways relevant to autoimmune and inflammatory diseases.
• Mechanism of Action Studies: Employed to elucidate degradation kinetics, ternary complex formation, and selectivity profiles in cellular models.
• Biomarker Identification: Aids in discovering pharmacodynamic biomarkers associated with effective IRAK4 degradation.
• High-Throughput Screening: Serves as a reference compound in assays designed to discover next-generation IRAK4 degraders or inhibitors.

Basic Information

Product Name	Protac Irak4 Degrader-1
CAS No.	2360533-90-8
Molecular Formula	C₄₀H₄₈ClN₉O₇
Molecular Weight	802.33 g/mol
Synonyms	PROTAC IRAK4 degrader-1; IRAK4 Degrader-1; IRAK4 PROTAC; (S,R,S)-AHPC-PEG4-C6-NH-C3-amide-4-fluoro-2-methyl-1H-indole-6-carboxylic acid; Degrader of IRAK4; IRAK4-targeting PROTAC; BMS-986
EINECS	Contact for details

Quality Control

Every batch of Protac Irak4 Degrader-1 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and stability. Our products are supplied with full traceability and are supported by a detailed Certificate of Analysis (COA) that includes data from HPLC, NMR, and MS. We adhere to high-purity standards typical for advanced pharmaceutical intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.