Description

Protac Crbn Degrader-1 is a potent and selective small molecule degrader designed for targeted protein degradation research. This compound is a critical tool for investigating the ubiquitin-proteasome system and developing novel therapeutic strategies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, neurodegenerative diseases, and other areas of targeted protein degradation.

Application

• Targeted Protein Degradation (TPD) Research: A key chemical probe for studying PROTAC (Proteolysis Targeting Chimera) mechanisms and CRBN (Cereblon) E3 ligase engagement.
• Drug Discovery & Preclinical Development: Used in hit-to-lead optimization and proof-of-concept studies for novel degrader molecules.
• Biochemical & Cellular Assays: Employed to validate target engagement, measure degradation kinetics (DC50), and assess maximal degradation (Dmax) in cell-based models.
• Oncology Research: Investigated for the degradation of oncogenic proteins and the exploration of new cancer therapeutics.
• Mechanism of Action (MoA) Studies: Essential for understanding the ternary complex formation and ubiquitination processes specific to CRBN-based degraders.
• High-Throughput Screening (HTS): Serves as a reference standard or positive control in screening campaigns for new E3 ligase binders.

Basic Information

Product Name	Protac Crbn Degrader-1
CAS No.	2358775-70-7
Molecular Formula	C30H31F3N6O6
Molecular Weight	628.60 g/mol
Synonyms	PROTAC CRBN Degrader-1; CRBN Degrader-1; dBET1; (S,R,S)-AHPC-Me; (S,R,S)-AHPC-methyl; (S,R,S)-AHPC-C1-NH2; ARV-825 (related analog); Thalidomide derivative; Cereblon ligand conjugate
EINECS	Contact for details

Quality Control

Our Protac Crbn Degrader-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC purity analysis, LC-MS for identity confirmation, and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and batch-specific data are provided to ensure reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to molecular ion [M+H]+
Purity (HPLC)	≥95% (Area Percent)
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.