Description

Thalidomide-C2-Amido-C2-Cooh is a synthetic, high-purity chemical intermediate designed for advanced pharmaceutical research and development. This compound is engineered to provide a critical building block for the synthesis of novel therapeutic agents, particularly in the fields of oncology and immunology. It is essential for medicinal chemists and R&D departments in pharmaceutical and biotechnology companies seeking to develop targeted protein degradation therapies and other innovative treatment modalities.

Application

• PROTAC (Proteolysis Targeting Chimera) Development: Serves as a key linker component connecting E3 ligase ligands to target protein binders.
• Molecular Glue Research: Used in the design and synthesis of compounds that induce novel protein-protein interactions for targeted degradation.
• Pharmaceutical Intermediate: Acts as a crucial synthetic precursor in the multi-step synthesis of investigational new drugs (INDs).
• Chemical Biology Probes: Utilized for creating tool compounds to study cellular pathways and protein function.
• Bioconjugation: Employed in the modification of biomolecules due to its reactive carboxylic acid and amide functionalities.
• Academic & Institutional Research: Supports fundamental research in drug discovery mechanisms at universities and research institutes.

Basic Information

Product Name	Thalidomide-C2-Amido-C2-Cooh
CAS No.	2353496-84-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2-(2-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamido)acetic acid; Thalidomide-based C2 linker with terminal carboxylic acid; Thalidomide-C2-NH-C2-COOH; E3 Ligase Ligand Linker; Cereblon Ligand Derivative; PROTAC Linker Intermediate; (S)-2-(2-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamido)acetic acid (common isomer reference)
EINECS	Contact for details

Quality Control

Our Thalidomide-C2-Amido-C2-Cooh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.