Description

T-Boc-Aminooxy-Peg8-Alcohol CAS NO 2353410-14-5 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a tert-butoxycarbonyl (Boc)-protected aminooxy group and a terminal hydroxyl group. This compound is engineered for precision bioconjugation, offering a controlled, site-specific linking strategy for attaching biomolecules, polymers, or surfaces under mild conditions. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science, where reliable and reproducible linker chemistry is critical.

Application

• Bioconjugation and Crosslinking: Site-specific conjugation of aldehydes or ketones from carbohydrates, oxidized glycoproteins, or small molecules to hydroxyl-functionalized surfaces or polymers.
• ADC (Antibody-Drug Conjugate) Linker Development: Serves as a functionalized PEG spacer arm to construct cleavable or non-cleavable linkers, improving drug solubility and pharmacokinetics.
• PEGylation Reagent: Used to introduce a protected aminooxy handle onto peptides, proteins, or nanoparticles, which can be later deprotected for further functionalization.
• Surface Functionalization: Modification of glass, gold, or polymer surfaces with a hydroxyl-terminated, hydrophilic PEG layer for creating non-fouling biointerfaces or sensor platforms.
• Hydrogel Formation: Acts as a crosslinker or functional monomer in the synthesis of smart hydrogels for drug delivery or tissue engineering applications.
• Chemical Biology Probes: Synthesis of activity-based probes or affinity tags for labeling and studying biomolecules in complex biological systems.

Basic Information

Item	Detail
Product Name	T-Boc-Aminooxy-Peg8-Alcohol
CAS No.	2353410-14-5
Molecular Formula	C27H55NO13
Molecular Weight	601.73 g/mol
Synonyms	1-Amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-ol, 26-[(1,1-Dimethylethoxy)carbonyl]amino]oxy]-; Boc-NH-O-PEG8-OH; tert-Butyl N-(8-hydroxy-3,6,9,12,15,18,21,24-octaoxaoctacos-1-yl-27-oxyl)carbamate; Aminooxy-PEG8-alcohol, Boc-protected; Boc-Aminooxy-PEG8-OH; (Boc-aminooxy)-octaethylene glycol; α-Boc-amino-ω-hydroxy-octa(ethylene glycol)
EINECS	Contact for details

Quality Control

Our T-Boc-Aminooxy-Peg8-Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for water content, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DCM, DMF, DMSO, Acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.