Description

n-Desthiobiotin-n-Bis(Peg4-T-Butyl Ester) is a high-purity, bifunctional chemical intermediate designed for advanced bioconjugation and linker chemistry. This compound is critical for researchers and manufacturers requiring precise, stable, and non-cleavable PEG-based spacers in their synthesis workflows. It is primarily utilized in the development of novel pharmaceuticals, diagnostic reagents, and sophisticated research tools within the life sciences and biotechnology sectors.

Application

• Bioconjugation Linker: Serves as a key building block for attaching targeting molecules (e.g., antibodies, peptides) to drugs, dyes, or solid surfaces via its reactive termini.
• ADC (Antibody-Drug Conjugate) Development: Used in the synthesis of stable linkers for connecting cytotoxic payloads to monoclonal antibodies, enhancing therapeutic efficacy and stability.
• Proteomics Research: Employed in the design of affinity probes and pull-down reagents for studying protein-protein interactions and post-translational modifications.
• Diagnostic Reagent Synthesis: Integral for creating advanced diagnostic assays, including ELISA and lateral flow tests, by providing a hydrophilic PEG spacer to reduce steric hindrance.
• Polymer & Material Science: Acts as a functional monomer or cross-linker for creating specialized hydrogels and biomaterials with tailored properties for drug delivery or tissue engineering.
• Chemical Biology Tool Development: Utilized to synthesize activity-based probes and other chemical tools for labeling and visualizing biological processes in cells.

Basic Information

Item	Details
Product Name	n-Desthiobiotin-n-Bis(Peg4-T-Butyl Ester)
CAS No.	2353409-60-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Desthiobiotin-PEG4-t-butyl ester; Bis(PEG4-t-butyl ester) Desthiobiotin; n-Desthiobiotin, N-bis(PEG4-t-butyl ester); 2,5-Dioxopyrrolidin-1-yl 3-((2-(2-(2-(2-(3-(2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)propanoate (desthiobiotin conjugate); PEG4-Desthiobiotin-t-Butyl Ester; Biotin-PEG4-t-Butyl Ester Analog; Long-chain Desthiobiotin Derivative
EINECS	Contact for details

Quality Control

Our n-Desthiobiotin-n-Bis(Peg4-T-Butyl Ester) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.