Description

E3 Ligase Ligand-Linker Conjugates 49 is a high-purity, synthetic small molecule designed for the targeted degradation of proteins via the PROTAC (PROteolysis TArgeting Chimera) technology platform. This compound is a critical research tool for developing novel therapeutics by hijacking the cell's natural ubiquitin-proteasome system to eliminate disease-causing proteins. It is essential for pharmaceutical R&D, biotechnology, and academic laboratories focused on oncology, neurodegenerative diseases, and other challenging therapeutic areas. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for your critical experiments.

Application

• PROTAC Molecule Development: Serves as a key building block for synthesizing heterobifunctional PROTAC degraders targeting specific proteins of interest.
• Chemical Biology Research: Used in mechanistic studies to understand E3 ligase engagement, ternary complex formation, and ubiquitination kinetics.
• Drug Discovery Platforms: Integral to high-throughput screening and structure-activity relationship (SAR) studies for identifying lead degradation compounds.
• Target Validation: Enables the functional interrogation of novel drug targets by assessing their susceptibility to ligand-induced degradation.
• Oncology & Immunology Research: Applied in pre-clinical research for degrading oncoproteins or immune-regulatory proteins to evaluate therapeutic potential.
• Bioconjugation & Probe Synthesis: Used to create activity-based probes or affinity matrices for studying protein interaction networks.

Basic Information

Product Name	E3 Ligase Ligand-Linker Conjugates 49
CAS No.	2351103-63-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker Conjugate 49; E3 Ligand-Linker 49; Degrader Building Block 49; Ubiquitin Ligase Recruiter 49; Targeted Protein Degradation Tool Compound 49; (S,R,S)-AHPC-PEG3-C2-Cl; VHL Ligand-PEG3-Chloride Conjugate
EINECS	Contact for details

Quality Control

Every batch of E3 Ligase Ligand-Linker Conjugates 49 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity (HPLC), identity (NMR, HRMS), and other critical parameters to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. For long-term storage, keep the primary container in a sealed secondary container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (HRMS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.