Description

(S,R,S)-Ahpc-Me Tfa is a high-purity, non-natural amino acid derivative featuring a unique stereochemical configuration. This compound is a critical chiral building block and intermediate in advanced pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working in the synthesis of novel therapeutic agents, particularly in the fields of oncology and targeted protein degradation.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• PROTAC (Proteolysis Targeting Chimera) Development: Used in the construction of linker-warhead conjugates for targeted protein degradation platforms.
• Peptidomimetic Research: Serves as a constrained, non-natural amino acid analog for designing bioactive peptides with enhanced stability and specificity.
• Chemical Biology Probes: Employed in the development of tool compounds for studying enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Acts as a chiral auxiliary or precursor in stereoselective organic synthesis.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial manufacturing of advanced therapeutics.

Basic Information

Product Name	(S,R,S)-Ahpc-Me Tfa
CAS No.	2349429-68-9
Molecular Formula	C14H23F3N2O3
Molecular Weight	324.34 g/mol
Synonyms	(2S,3R,5S)-1-[(S)-2-Methylbutyryl]-N-[(3S)-2-oxo-3-pyrrolidinyl]-5-(2,2,2-trifluoroacetyl)amino-3-piperidinecarboxamide; (S,R,S)-Ahpc(Me)-TFA; (S,R,S)-Ahpc(Me)-Trifluoroacetamide; (2S,3R,5S)-5-[(2,2,2-Trifluoroacetyl)amino]-1-[(2S)-2-methylbutanoyl]-N-[(3S)-2-oxopyrrolidin-3-yl]piperidine-3-carboxamide; Ahpc-Me TFA derivative; (S,R,S) Ahpc Methyl Tfa; PROTAC Linker Amino Acid Derivative
EINECS	Contact for details

Quality Control

Our (S,R,S)-Ahpc-Me Tfa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.