Description

Recombinant Human Cyclin-Dependent Kinase Inhibitor 2A CAS NO 2332972-26-4 is a high-purity, biologically active protein critical for cell cycle regulation and cancer research. This recombinant inhibitor is essential for studying tumor suppressor pathways, apoptosis, and cellular senescence mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic research laboratories, and biotechnology companies focused on oncology drug discovery and molecular biology.

Application

• Biochemical Research & Assay Development: Used as a key reagent in enzymatic assays to study CDK inhibition kinetics and mechanisms of action.
• Oncology & Cancer Drug Discovery: Serves as a critical target protein for screening and validating novel therapeutic compounds aimed at restoring cell cycle control.
• Cell Biology Studies: Employed in vitro to investigate the roles of p16INK4a in cellular senescence, proliferation, and DNA damage response pathways.
• Diagnostic Development: Acts as a reference standard in the development of immunoassays and diagnostic kits for detecting p16 expression in clinical samples.
• Protein-Protein Interaction Analysis: Utilized in pull-down assays, co-immunoprecipitation, and surface plasmon resonance (SPR) to map interactions with cyclin-dependent kinases (CDKs).
• High-Throughput Screening (HTS): A vital component in automated screening platforms to identify potential CDK4/6 inhibitors from compound libraries.

Basic Information

Product Name	Recombinant Human Cyclin-Dependent Kinase Inhibitor 2A
CAS No.	2332972-26-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Recombinant p16INK4a; Recombinant CDKN2A; Recombinant Human p16; Cyclin-Dependent Kinase Inhibitor 2A (p16-INK4A); Tumor Suppressor p16; MTS1; INK4a; CDK4 Inhibitor p16; ARF; p14ARF (note: specific isoform should be confirmed)
EINECS	Contact for details

Quality Control

Our recombinant protein is produced under stringent conditions and undergoes rigorous quality testing to ensure high biological activity, purity, and batch-to-batch consistency. Each lot is characterized by SDS-PAGE, Western Blot, and functional activity assays. Certificates of Analysis (COA) detailing purity, endotoxin levels, and biological activity are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Identification (Western Blot)	Positive
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity (Cell-based Assay)	Contact for details
Protein Content (BCA)	Contact for details
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.