Description

Nav1.1 Activator 1 is a potent and selective small-molecule activator of the voltage-gated sodium channel Nav1.1 (SCN1A). This compound is a critical research tool for investigating sodium channel function and related neurological pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, ion channel biology, and drug discovery for neurological disorders.

Application

• Neuroscience Research: A key pharmacological tool for studying the functional role of Nav1.1 channels in neuronal excitability and signal transduction.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and lead optimization campaigns to identify and characterize novel therapeutics targeting sodium channels.
• Mechanistic Studies: Enables detailed investigation into channel gating kinetics, state-dependent modulation, and structure-activity relationships (SAR).
• Target Validation: Supports in vitro and ex vivo models to validate Nav1.1 as a therapeutic target for conditions like epilepsy, migraine, and neuropathic pain.
• Academic & Institutional Research: Essential for basic science research in university and hospital laboratories exploring ion channel physiology and pathophysiology.
• Biomarker Research: Facilitates studies on how Nav1.1 modulation affects cellular phenotypes, potentially leading to the identification of novel biomarkers.

Basic Information

Item	Details
Product Name	Nav1.1 Activator 1
CAS No.	2332897-85-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Nav1.1 Activator 1; SCN1A Activator 1; Voltage-Gated Sodium Channel Nav1.1 Activator; Nav1.1 Channel Opener; CAS 2332897-85-3; Sodium Channel Activator for SCN1A; Research Compound 2332897-85-3
EINECS	Contact for details

Quality Control

Our Nav1.1 Activator 1 is manufactured under strict quality control protocols to ensure high purity, batch-to-batch consistency, and reliable biological activity. Each lot is supported by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry. Certificates of Analysis (COA) are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (Cell-based Assay)	EC50 provided per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.