Description

Protac Brd4 Ligand-1 is a potent and selective small molecule degrader designed for targeted protein degradation research. This compound is a critical tool for investigating the role of BRD4 in epigenetic regulation and disease pathways, particularly in oncology. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on developing novel therapeutic strategies using PROTAC (Proteolysis Targeting Chimera) technology.

Application

• PROTAC Development & Validation: Serves as a key chemical probe for designing and optimizing BRD4-targeting PROTAC molecules.
• Epigenetics Research: Used to study BRD4 function and bromodomain biology in cellular models of cancer and other diseases.
• Drug Discovery Screening: Acts as a reference standard in high-throughput assays to identify and characterize new degraders.
• Mechanism of Action Studies: Enables investigation of ubiquitin-proteasome system (UPS) engagement and degradation kinetics.
• Preclinical Research: Utilized in in vitro and in vivo studies to validate target degradation and assess therapeutic potential.

Basic Information

Item	Details
Product Name	Protac Brd4 Ligand-1
CAS No.	2313230-51-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Brd4 Ligand-1; PROTAC BRD4 Ligand 1; BRD4 Degrader Ligand-1; (S,R,S)-AHPC-based VHL Ligand 1; VH032-based BRD4 Ligand; BET Degrader Ligand; BRD4-PROTAC Ligand; VHL E3 Ligase Ligand for BRD4; Chemical Probe for BRD4 Degradation
EINECS	Contact for details

Quality Control

Our Protac Brd4 Ligand-1 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided, documenting identity, purity, and other critical parameters to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.