Description

Ldn193189 Tetrahydrochloride is a potent and selective small molecule inhibitor of the BMP (Bone Morphogenetic Protein) type I receptors ALK2 and ALK3. This high-purity compound is essential for disrupting BMP signaling pathways in advanced biochemical and pharmacological research. It is a critical reagent for scientists in pharmaceutical R&D and academic institutions studying bone development, stem cell differentiation, and related disease mechanisms. CAS No. 2310134-98-4.

Application

• Biochemical Research: A key tool for studying BMP signaling pathways, receptor inhibition kinetics, and downstream cellular effects.
• Stem Cell Biology: Used to direct stem cell fate by inhibiting BMP signaling, promoting neural differentiation, and maintaining pluripotency under specific conditions.
• Pharmaceutical Development: Serves as a reference standard and lead compound in drug discovery programs targeting fibrodysplasia ossificans progressiva (FOP), anemia, and other BMP-related disorders.
• Cancer Research: Investigated for its role in modulating tumor microenvironments and cellular processes in certain cancers where BMP signaling is implicated.
• Developmental Biology: Employed in model organism studies to understand the role of BMP in embryogenesis, organogenesis, and tissue patterning.

Basic Information

Product Name	Ldn193189 Tetrahydrochloride
CAS No.	2310134-98-4
Molecular Formula	C₂₆H₂₈Cl₄N₄O₃
Molecular Weight	578.33 g/mol
Synonyms	LDN-193189 HCl; LDN193189 HCl; 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline tetrahydrochloride; DM-3189; DM3189; BMP Inhibitor LDN 193189; BMP Type I Receptor Inhibitor II; ALK2/ALK3 Inhibitor
EINECS	Contact for details

Quality Control

Our Ldn193189 Tetrahydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals, and specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.