Description

E3 Ligase Ligand-Linker Conjugates 15 is a high-purity, synthetic chemical building block designed for the development of Proteolysis-Targeting Chimeras (PROTACs) and other targeted protein degradation (TPD) technologies. This compound matters because it provides a critical, functionalized component that links an E3 ubiquitin ligase recruiter to a protein-of-interest (POI) binder, enabling the precise hijacking of the cell's natural degradation machinery. It is essential for researchers and developers in pharmaceutical R&D, biotechnology, and academic institutions focused on creating novel therapeutics for oncology, neurodegenerative diseases, and other challenging targets.

Application

• Core Component in PROTAC Synthesis: Serves as a key linker-ligand conjugate for constructing heterobifunctional PROTAC molecules.
• Targeted Protein Degradation (TPD) Research: Used in the development and optimization of degrader platforms for "undruggable" targets.
• Chemical Biology Tool Development: Enables the study of ubiquitin-proteasome system (UPS) pathways and protein function.
• Preclinical Drug Discovery: Integral for hit-to-lead and lead optimization stages in novel therapeutic programs.
• Bioconjugation and Probe Design: Utilized for creating activity-based probes to study E3 ligase engagement and kinetics.
• Library Synthesis for Screening: A valuable building block for generating diverse libraries of PROTAC candidates for high-throughput screening.

Basic Information

Item	Details
Product Name	E3 Ligase Ligand-Linker Conjugates 15
CAS No.	2308035-51-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker-Ligand Conjugate 15; E3 Ligase Recruiter-Linker 15; Targeted Degradation Building Block 15; TPD Conjugate 15; Ubiquitin Ligase Ligand-Linker; Heterobifunctional Molecule Precursor 15; (S,R,S)-AHPC-PEG3-C2-Cl (related common core structure example)
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand-Linker Conjugates 15 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive biological research. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.