Description

Protac Errα Degrader-2 is a potent and selective small molecule degrader designed to target the estrogen-related receptor alpha (ERRα) for proteasomal degradation. This compound is a critical research tool for investigating ERRα biology and its role in metabolic diseases, oncology, and other therapeutic areas. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on targeted protein degradation and drug discovery.

Application

• Targeted Protein Degradation Research: A key chemical probe for studying PROTAC (Proteolysis Targeting Chimera) technology and the pharmacological knockdown of ERRα.
• Oncology Research: Investigation of ERRα's role in cancer cell metabolism, proliferation, and tumor progression, particularly in breast, ovarian, and prostate cancers.
• Metabolic Disease Studies: Exploration of ERRα function in mitochondrial biogenesis, fatty acid oxidation, and glucose metabolism for potential therapeutic interventions.
• Mechanistic Biology: Used to elucidate signaling pathways and validate ERRα as a therapeutic target in various cellular and animal models.
• Drug Discovery & Preclinical Development: Serves as a lead compound or reference standard for developing novel ERRα-targeted therapies.
• Biochemical Assays: Employed in high-throughput screening (HTS), binding assays, and functional studies to assess compound efficacy and selectivity.

Basic Information

Product Name	Protac Errα Degrader-2
CAS No.	2306388-85-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ERRα Degrader-2; PROTAC ERRα Degrader 2; ERRα PROTAC; Estrogen-Related Receptor Alpha Degrader-2; PROTAC ERR-alpha Degrader-2; Degrader of ERRα; (S,R,S)-AHPC-PEG3-GSK5182 (common structural descriptor); Targeted ERRα Degrader
EINECS	Contact for details

Quality Control

Our Protac Errα Degrader-2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.