Description

Protac Errα Ligand 2 (CAS NO 2306388-57-6) is a high-purity, synthetic small molecule designed for targeted protein degradation research. This compound serves as a critical ligand component in the construction of Proteolysis-Targeting Chimeras (PROTACs) specifically targeting the estrogen-related receptor alpha (ERRα). It is essential for pharmaceutical R&D and academic laboratories focused on developing novel therapeutic strategies in oncology, metabolic diseases, and other conditions linked to ERRα signaling pathways.

Application

• PROTAC Molecule Synthesis: A key building block for constructing bifunctional PROTAC degraders targeting the ERRα protein.
• Chemical Biology Research: Used in studies to understand ERRα function, protein-protein interactions, and degradation pathways via the ubiquitin-proteasome system.
• Drug Discovery & Preclinical Development: Enables the exploration of targeted protein degradation as a therapeutic modality for cancers dependent on ERRα.
• Biochemical Assay Development: Serves as a reference standard or competitor in binding assays (e.g., SPR, ITC) to evaluate ligand-protein interactions.
• Academic & Institutional Research: Fundamental tool for investigating nuclear receptor biology and novel pharmacological mechanisms.

Basic Information

Product Name	Protac Errα Ligand 2
CAS No.	2306388-57-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ERRα Ligand 2; PROTAC ERRα Ligand; Estrogen-Related Receptor Alpha Ligand 2; ERRα-targeting PROTAC Ligand; Degrader Ligand for ERRα; (2S,4R)-1-((S)-2-(1-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (IUPAC); PROTAC ERRα Degrader Component.
EINECS	Contact for details

Quality Control

Our Protac Errα Ligand 2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, mass spectrometry (MS) for identity confirmation, and NMR spectroscopy. A detailed Certificate of Analysis (COA) containing all specification data is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.