Description

Protac Fak Degrader 1 is a potent and selective small molecule PROTAC (PROteolysis TArgeting Chimera) designed for targeted protein degradation research. This compound is a critical tool for investigating novel therapeutic strategies in oncology and other disease areas by facilitating the ubiquitin-proteasome system-mediated degradation of specific target proteins. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on drug discovery and molecular biology.

Application

• Targeted Protein Degradation Research: A core chemical probe for validating PROTAC technology and studying the effects of specific protein knockdown.
• Oncology Drug Discovery: Used in preclinical studies to evaluate the efficacy of degrading oncogenic proteins for potential cancer therapy development.
• Mechanistic Biology Studies: Enables the exploration of protein function and signaling pathways in cellular models by inducing selective protein removal.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in assays designed to discover new degraders or E3 ligase binders.
• Chemical Biology Tool: Used to study ubiquitin-proteasome system dynamics and the kinetics of induced proteolysis.
• Biomarker Identification: Helps in identifying downstream effects and potential resistance mechanisms following targeted protein degradation.

Basic Information

Product Name	Protac Fak Degrader 1
CAS No.	2301916-69-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC FAK degrader 1; FAK-targeting PROTAC; CAS 2301916-69-6; Fak Degrader 1; Targeted Fak Degrader; Proteolysis-targeting chimera for Fak; (S,R,S)-AHPC-based FAK degrader; PROTAC-based FAK inhibitor
EINECS	Contact for details

Quality Control

Our Protac Fak Degrader 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and mass spectrometry for identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.