Description

Ripk1-In-7 CAS NO 2300982-44-7 is a potent and selective small-molecule inhibitor of the Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), a key regulator of inflammation and cell death pathways. This compound is a critical research tool for investigating the role of RIPK1 in inflammatory diseases, neurodegenerative conditions, and cancer biology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics targeting necroptosis and inflammatory signaling cascades.

Application

• Biomedical Research: Used as a selective chemical probe to study RIPK1-mediated necroptosis and apoptosis in cellular models.
• Drug Discovery & Development: Serves as a reference compound or lead structure for developing new anti-inflammatory and neuroprotective agents.
• Inflammatory Disease Models: Applied in preclinical research for conditions like rheumatoid arthritis, inflammatory bowel disease (IBD), and psoriasis.
• Neurodegenerative Disease Research: Investigated in models of Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, and Multiple Sclerosis (MS).
• Oncology Research: Explored for its potential to sensitize cancer cells to other treatments by modulating cell death pathways.
• Signal Pathway Analysis: Essential for elucidating the complex interplay between TNFα signaling, NF-κB activation, and cell survival.

Basic Information

Product Name	Ripk1-In-7
CAS No.	2300982-44-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	RIPK1-IN-7; RIPK1 Inhibitor-7; Receptor-interacting serine/threonine-protein kinase 1 inhibitor 7; 2300982-44-7; RIP1 kinase inhibitor; Necroptosis inhibitor RIPK1; RIPK1 chemical probe
EINECS	Contact for details

Quality Control

Our Ripk1-In-7 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and other relevant specifications is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under desiccated conditions. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.