Description

8-Arm Peg-Mal is a multi-arm, heterobifunctional polyethylene glycol derivative featuring a maleimide (Mal) functional group at each terminus. This high-purity, multi-valent linker is engineered for creating stable, high-density bioconjugates and advanced hydrogel networks. It is essential for researchers and manufacturers in the biopharmaceutical and advanced materials sectors who require precise, high-loading capacity for attaching thiol-containing molecules like peptides, proteins, and antibodies. Its branched architecture enables the construction of complex, well-defined macromolecular structures with enhanced functionality.

Application

• Bioconjugation & Drug Delivery: Site-specific conjugation of thiolated drugs, antibodies (ADCs), or targeting ligands to create multi-valent therapeutic constructs.
• Hydrogel Formation: Cross-linking agent for creating tunable, biocompatible hydrogel matrices for 3D cell culture, tissue engineering, and controlled release systems.
• Surface Functionalization: Modification of gold surfaces or other materials with thiol groups to create multi-arm PEGylated, protein-resistant coatings.
• Protein & Peptide Modification: Introduction of multiple PEG chains (PEGylation) to proteins or peptides via cysteine residues to improve solubility, stability, and pharmacokinetics.
• Diagnostic Reagent Synthesis: Building block for creating multi-epitope diagnostic probes or contrast agents with high signal density.
• Nanoparticle & Liposome Coating: Creating dense, multi-anchored PEG shells on nanoparticles to enhance stealth properties and colloidal stability.

Basic Information

Item	Details
Product Name	8-Arm Peg-Mal
CAS No.	2286326-40-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details (Grade Dependent)
Synonyms	8-Arm PEG Maleimide; Octa-Arm PEG-Maleimide; 8-Arm Polyethylene Glycol Maleimide; Multi-Arm PEG-Mal; Octafunctional PEG Maleimide; 8-Arm PEG-MAL; Maleimide-terminated 8-arm PEG; Star-PEG Maleimide
EINECS	Contact for details

Quality Control

Every batch of our 8-Arm Peg-Mal is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming critical parameters such as functional group substitution, purity (by HPLC/GPC), molecular weight distribution, and residual solvent content. Our quality commitment ensures reproducible performance for your most sensitive R&D and cGMP-grade manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis of the maleimide groups.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR / NMR)	Conforms to structure
Assay (Functional Group)	≥ 95% (Maleimide substitution)
Purity (HPLC / GPC)	≥ 95%
Molecular Weight (Mn)	As per ordered grade (e.g., 10kDa, 20kDa, 40kDa)
Polydispersity Index (PDI)	≤ 1.05 (GPC)
Moisture Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.