Description

Csf1R-In-2 CAS NO 2271119-26-5 is a potent and selective small molecule inhibitor targeting the Colony Stimulating Factor 1 Receptor (CSF1R), a key tyrosine kinase involved in regulating macrophage and microglia function. This compound is crucial for advancing research in oncology, neuroinflammation, and autoimmune diseases by providing a precise tool to modulate the tumor microenvironment and immune cell signaling. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in drug discovery programs for cancer immunotherapy and neurodegenerative conditions.

Application

• Drug Discovery & Preclinical Research: A critical tool for in vitro and in vivo studies investigating the role of CSF1R signaling pathways in various disease models.
• Oncology Research: Used to study tumor-associated macrophages (TAMs) and their impact on tumor progression, metastasis, and response to immunotherapy.
• Neuroinflammation Studies: Applied in research targeting microglia in models of neurodegenerative diseases such as Alzheimer's, Parkinson's, and multiple sclerosis.
• Autoimmune Disease Research: Facilitates the exploration of macrophage-driven inflammation in conditions like rheumatoid arthritis and inflammatory bowel disease.
• Biomarker Development: Serves as a reference compound for developing and validating assays to measure CSF1R inhibition and downstream biological effects.
• Lead Optimization: Provides a structural scaffold for medicinal chemistry programs aimed at developing novel CSF1R inhibitors with improved pharmacokinetic properties.

Basic Information

Product Name	Csf1R-In-2
CAS No.	2271119-26-5
Molecular Formula	C₂₅H₂₇N₅O₃
Molecular Weight	445.51 g/mol
Synonyms	CSF1R Inhibitor 2; CSF1R-IN-2; 2271119-26-5; Colony Stimulating Factor 1 Receptor Inhibitor 2; (S)-N-(5-Chloro-4-((1-(2-isobutyryl-3-methyl-1H-indol-5-yl)ethyl)amino)pyrimidin-2-yl)-2-methylazetidine-1-sulfonamide; AZD-7507; AZD7507
EINECS	Contact for details

Quality Control

Our Csf1R-In-2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, potency, and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.