Description

E3 Ligase Ligand-Linker Conjugates 50 (CAS No. 2271036-44-1) represents a sophisticated class of bifunctional molecules designed for targeted protein degradation research. These conjugates are critical for constructing Proteolysis-Targeting Chimeras (PROTACs), enabling the precise hijacking of the cell's natural ubiquitin-proteasome system to degrade disease-causing proteins. This product is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on advancing novel therapeutic modalities in oncology, neurodegenerative diseases, and beyond.

Application

• PROTAC Molecule Synthesis: Core building block for constructing heterobifunctional degraders by conjugating to a target protein-binding warhead.
• Chemical Biology Research: Tool compound for studying E3 ligase engagement, ubiquitination kinetics, and substrate specificity.
• Drug Discovery Platforms: Enables the development of targeted protein degradation (TPD) libraries for high-throughput screening.
• Oncology & Immunology R&D: Facilitates the degradation of historically "undruggable" targets in cancer and immune signaling pathways.
• Mechanism of Action Studies: Used to validate the role of specific E3 ligases in cellular protein turnover and disease models.
• Linker Optimization: Serves as a key reagent for investigating structure-activity relationships (SAR) of linker composition and length on PROTAC efficacy and pharmacokinetics.

Basic Information

Product Name	E3 Ligase Ligand-Linker Conjugates 50
CAS No.	2271036-44-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker Conjugate; E3 Ligase Recruiting Moiety; Heterobifunctional Degrader Core; Ubiquitin Ligase Ligand-Linker; Targeted Protein Degradation Reagent; Cereblon or VHL Ligand Conjugate; Bifunctional Molecule for PROTACs; Protein Degradation Chemical Probe
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand-Linker Conjugates 50 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, LC-MS, and NMR to confirm identity, purity, and structural integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the product may be stored desiccated at 2-8°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.