Description

Egfr-In-7 (Compound 34) is a potent and selective small-molecule inhibitor of the Epidermal Growth Factor Receptor (EGFR), a key target in oncology research. This compound matters for its high specificity and utility in dissecting EGFR-mediated signaling pathways and evaluating therapeutic strategies. Researchers in pharmaceutical R&D, academic institutions, and biotechnology companies need it for use as a critical biochemical tool in cancer biology studies, high-throughput screening, and preclinical drug discovery programs.

Application

• Biochemical Research: Used as a selective probe to study EGFR kinase activity, downstream signaling cascades, and cellular proliferation mechanisms.
• Drug Discovery & Development: Serves as a reference compound and a lead structure in the design and optimization of novel EGFR-targeted anticancer agents.
• Cellular Assays: Employed in cell-based assays to investigate the effects of EGFR inhibition on tumor cell growth, apoptosis, and migration.
• High-Throughput Screening (HTS): Utilized as a control or validation compound in HTS campaigns to identify new EGFR inhibitors.
• Mechanistic Studies: Applied in research to understand resistance mechanisms to existing EGFR tyrosine kinase inhibitors (TKIs).
• Preclinical Evaluation: Used in animal models to assess the in vivo efficacy and pharmacokinetic profile of EGFR inhibition.

Basic Information

Product Name	Egfr-In-7 (Compound 34)
CAS No.	2267329-76-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	EGFR-IN-7; Compound 34; EGFR Inhibitor 7; N-[3-[[5-Chloro-2-[(1-methyl-4-piperidyl)amino]pyrimidin-4-yl]amino]-4-methylphenyl]-4-(dimethylamino)but-2-enamide; (E)-N-(3-((5-chloro-2-((1-methylpiperidin-4-yl)amino)pyrimidin-4-yl)amino)-4-methylphenyl)-4-(dimethylamino)but-2-enamide
EINECS	Contact for details

Quality Control

Our Egfr-In-7 (Compound 34) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee reproducible performance in your research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion
Purity (HPLC)	≥95%
Water Content	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.