Description

Bcl6-In-5 CAS NO 2253878-09-8 is a potent and selective small molecule inhibitor of the B-cell lymphoma 6 (Bcl6) protein, a key transcriptional repressor involved in germinal center formation and lymphomagenesis. This compound is a critical research tool for investigating Bcl6-mediated oncogenic pathways and for the preclinical development of novel therapeutics targeting diffuse large B-cell lymphoma (DLBCL) and other B-cell malignancies. It is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology and immunology.

Application

• Oncological Research: Used as a chemical probe to study the role of Bcl6 in B-cell development, differentiation, and the pathogenesis of lymphomas like DLBCL.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for novel Bcl6 inhibitors.
• Mechanistic Studies: Enables the dissection of Bcl6-co-repressor interactions and its downstream signaling pathways in cellular and animal models.
• Preclinical Validation: Utilized in in vitro and in vivo models to validate Bcl6 as a therapeutic target and assess the efficacy of targeted therapies.
• Biomarker Research: Aids in research correlating Bcl6 expression and inhibition with treatment response and patient outcomes.

Basic Information

Product Name	Bcl6-In-5
CAS No.	2253878-09-8
Molecular Formula	C₂₉H₂₈N₆O₃
Molecular Weight	508.57 g/mol
Synonyms	Bcl6 Inhibitor-5; Bcl6-IN-5; 2253878-09-8; B-cell lymphoma 6 inhibitor 5; (S)-N-(3-(4-((2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methyl)piperazin-1-yl)phenyl)-6-(4-methyl-1H-imidazol-1-yl)picolinamide
EINECS	Contact for details

Quality Control

Our Bcl6-In-5 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including purity verification by HPLC and structural confirmation by NMR and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and strength.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture. For short-term storage (weeks), the material may be kept at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.