Description

Pkc-Theta Inhibitor Hcl CAS NO 2253640-49-0 is a potent and selective small molecule inhibitor of the protein kinase C theta (PKC-θ) enzyme. This compound is of significant value for biochemical and pharmacological research, particularly in the study of T-cell activation and immune-mediated diseases. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on immunology, autoimmune disorders, and oncology drug discovery.

Application

• Biochemical Research: Used as a selective tool compound to study the role of PKC-θ in intracellular signaling pathways.
• Immunology Studies: Critical for investigating T-cell receptor (TCR) signaling, T-cell activation, and immune synapse formation.
• Drug Discovery: Serves as a reference standard and lead compound in the development of novel therapeutics for autoimmune diseases (e.g., rheumatoid arthritis, psoriasis) and transplant rejection.
• Cellular Assays: Employed in high-throughput screening (HTS) and in vitro cell-based assays to evaluate PKC-θ inhibition efficacy.
• Mechanism of Action (MoA) Studies: Utilized to elucidate the specific biological functions and downstream effects of PKC-θ inhibition.
• Preclinical Research: Applied in animal model studies to validate PKC-θ as a therapeutic target for various inflammatory and oncological conditions.

Basic Information

Product Name	Pkc-Theta Inhibitor Hcl
CAS No.	2253640-49-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PKCθ Inhibitor Hydrochloride; Protein Kinase C Theta Inhibitor HCl; 2253640-49-0; PKC-theta Inhibitor; PKCθ Inhibitor; PKC Theta Inhibitor; (Chemical Name Pending IUPAC Assignment); Research Compound 2253640-49-0
EINECS	Contact for details

Quality Control

Our Pkc-Theta Inhibitor Hcl is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Potency (Biochemical Assay)	IC50 provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.