Description

Protac Mdm2 Degrader-2 is a potent and selective small-molecule degrader designed to target the MDM2 protein for proteasomal degradation. This compound is a critical research tool in oncology and molecular biology, enabling the study of the p53 tumor suppressor pathway and its role in cancer cell proliferation. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on targeted protein degradation (TPD) and novel cancer therapeutic discovery.

Application

• Targeted Protein Degradation (TPD) Research: A key PROTAC (PROteolysis TArgeting Chimera) molecule for validating the TPD platform and studying ubiquitin-proteasome system (UPS) kinetics.
• Oncology and Cancer Biology Studies: Used to investigate the MDM2-p53 interaction axis, reactivate p53 function, and induce apoptosis in cancer cell lines.
• Drug Discovery & Preclinical Development: Serves as a lead compound or positive control in high-throughput screening (HTS) assays for developing next-generation cancer therapeutics.
• Mechanistic Studies: Facilitates research into protein-protein interactions, ternary complex formation, and the specificity of E3 ligase recruitment.
• Biomarker and Pathway Analysis: A tool compound for elucidating downstream effects of MDM2 degradation on gene expression and cellular signaling networks.

Basic Information

Product Name	Protac Mdm2 Degrader-2
CAS No.	2249944-99-6
Molecular Formula	C₄₇H₅₅ClN₆O₇S
Molecular Weight	883.49 g/mol
Synonyms	PROTAC MDM2 Degrader-2; MD-224; (S,R,S)-AHPC-MDM2 Ligand-Linker Conjugate 2; VHL Ligand-Linker Conjugates 12; (S,R,S)-AHPC-C6-NH-C5-VHL Ligand 2; Degrader of MDM2; PROTAC-based MDM2 Degrader. Contact for additional IUPAC name.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Protac Mdm2 Degrader-2 is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing lot-specific results for HPLC purity, NMR, and mass spectrometry are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥95% (Area Percent)
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.