Description

Protac Mdm2 Degrader-1 is a potent and selective small molecule degrader designed for targeted protein degradation research. This compound functions as a heterobifunctional PROTAC (PROteolysis TArgeting Chimera), specifically engineered to recruit the E3 ubiquitin ligase to the MDM2 oncoprotein, leading to its ubiquitination and subsequent proteasomal degradation. It is an essential research tool for oncology and molecular biology studies focused on the p53 tumor suppressor pathway. Researchers in pharmaceutical R&D and academic institutions utilize this molecule to investigate novel cancer therapeutics and validate new drug discovery platforms.

Application

• Targeted Protein Degradation Research: A key tool for validating the PROTAC platform and studying ubiquitin-proteasome system (UPS) dynamics.
• Oncology and Cancer Biology Studies: Used to investigate the therapeutic potential of degrading MDM2 to reactivate the p53 pathway in various cancer cell lines and models.
• Mechanism of Action (MOA) Studies: Enables detailed pharmacological studies to understand the kinetics and efficacy of induced protein degradation.
• Biochemical Assay Development: Utilized in high-throughput screening (HTS) and in vitro assays to identify and characterize new E3 ligase binders or linkers.
• Signal Transduction Pathway Analysis: Helps elucidate the role of MDM2 in cellular processes like apoptosis, cell cycle regulation, and DNA damage response.

Basic Information

Product Name	Protac Mdm2 Degrader-1
CAS No.	2249944-98-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC MDM2 Degrader-1; MDM2 Degrader-1; PROTAC® MDM2 Degrader-1; (S,R,S)-AHPC-MDM2 Ligand; VHL Ligand-Lenalidomide-based MDM2 Degrader; VH032-MDM2 Degrader; Cereblon-based MDM2 Degrader; E3 Ligase Ligand-Linker Conjugate
EINECS	Contact for details

Quality Control

Our Protac Mdm2 Degrader-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to industry best practices to support your reproducible research and preclinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.