Description

Protac Mdm2 Degrader-4 CAS NO 2249750-24-9 is a potent and selective small-molecule degrader designed for targeted protein degradation (TPD) research, specifically targeting the MDM2 protein for ubiquitin-proteasome system-mediated degradation. This compound is a critical tool for advancing oncology and molecular biology research, enabling the study of p53 pathway reactivation and novel therapeutic strategies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer drug discovery and proteolysis-targeting chimera (PROTAC) technology development.

Application

• PROTAC & Targeted Protein Degradation Research: A key chemical probe for studying the mechanisms and efficacy of heterobifunctional degraders.
• Oncology & Cancer Biology Studies: Used to investigate tumor suppression via p53 pathway activation by degrading its negative regulator, MDM2.
• High-Throughput Screening (HTS): Serves as a reference standard or active control in assays screening for novel degraders or MDM2 inhibitors.
• Preclinical Drug Development: Employed in in vitro and in vivo models to validate degradation efficacy, pharmacokinetics, and therapeutic potential.
• Mechanistic Biology: Facilitates the exploration of ubiquitin ligase engagement, ternary complex formation, and protein turnover kinetics.
• Chemical Biology Tool Compound: Used to create cellular models of MDM2 loss-of-function to study downstream biological consequences.

Basic Information

Product Name	Protac Mdm2 Degrader-4
CAS No.	2249750-24-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC MDM2 Degrader-4; MDM2 Degrader-4; PROTAC Mdm2 Degrader 4; (S,R,S)-AHPC-MDM2 Ligand 4; VHL Ligand-Lenalidomide-based MDM2 Degrader; Compound 4 (from PROTAC MDM2 Degrader series); E3 Ligase Ligand-Linker Conjugate
EINECS	Contact for details

Quality Control

Our Protac Mdm2 Degrader-4 is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under desiccated conditions. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.